Prevalence of Celiac Disease in adult patients with Non-Cirrhotic Portal Fibrosis

Background and Aim: Celiac Disease (CeD) is a multisystemic disease in addition to the small intestine, also affects liver. The spectrum of liver involvement CeD includes cryptogenic hypertransaminasaemia/cirrhosis, autoimmune diseases vascular like Non-cirrhotic portal fibrosis (NCPF). There lack systematic study on prevalence patients with NCPF. Methods: All new biopsy-proven NCPF reporting clinic were recruited. Additionally, database all other was reviewed they invited participate study. screened for using IgA anti-tissue transglutaminase antibody (anti-tTG Ab). Anti-tTG Ab-positive subjected anti-endomysial (AEA) testing duodenal biopsy examination. Liver biopsies corresponding IgA/anti-tTG colocalization studies immunohistochemistry. Results: Seventy-two Of them, 9 had anti-tTG Ab positive suggesting seroprevalence 12.5%. Most these strongly (mean fold rise 22 times above upper limit normal). Duodenal showed villous abnormalities modified Marsh grade 3 7 them be 9.7%. AEA 6 having abnormalities. duodenum demonstrable respectively. started gluten-free diet (GFD) being followed. Conclusion: are 12.5% 9.7% respectively, which substantially more than general population. While effects GFD unclear, based data this preliminary study, we suggest that should CeD.